2010
1.	Ng SF, Lin RC, Laybutt DR, Barres R, Owens JA, Morris MJ. Chronic high-fat diet in fathers programs beta-cell dysfunction in female rat offspring. Nature. 2010 Oct 21;467(7318):963-6. PubMed PMID: 20962845.
	Themes:  Diabetes/insulin resistance	
2.	Someya S, Yu W, Hallows WC, Xu J, Vann JM, Leeuwenburgh C, et al. Sirt3 mediates reduction of oxidative damage and prevention of age-related hearing loss under caloric restriction. Cell. 2010 Nov 24;143(5):802-12. PubMed PMID: 21094524. Pubmed Central PMCID: 3018849.
Themes:  Calorie restriction; Mitochondria, reactive oxygen species, and cellular energetics; Sirtuins	
3.	Qiu X, Brown K, Hirschey MD, Verdin E, Chen D. Calorie restriction reduces oxidative stress by SIRT3-mediated SOD2 activation. Cell Metab. 2010 Dec 1;12(6):662-7. PubMed PMID: 21109198.
Themes:  Calorie restriction; mitochondria, reactive oxygen species, and cellular energetics; Sirtuins
4.	Kume S, Uzu T, Horiike K, Chin-Kanasaki M, Isshiki K, Araki S, et al. Calorie restriction enhances cell adaptation to hypoxia through Sirt1-dependent mitochondrial autophagy in mouse aged kidney. J Clin Invest. 2010 Apr;120(4):1043-55. PubMed PMID: 20335657. Pubmed Central PMCID: 2846062.
	Themes:  Calorie restriction; Sirtuins
5.	Yang W, Hekimi S. A mitochondrial superoxide signal triggers increased longevity in Caenorhabditis elegans. PLoS Biol. 2010;8(12):e1000556. PubMed PMID: 21151885. Pubmed Central PMCID: 2998438.
	Themes:  Mitochondria, reactive oxygen species, and cellular energetics
6.	Onken B, Driscoll M. Metformin induces a dietary restriction-like state and the oxidative stress response to extend C. elegans Healthspan via AMPK, LKB1, and SKN-1. PLoS One. 2010;5(1):e8758. PubMed PMID: 20090912. Pubmed Central PMCID: 2807458.
Themes:  Calorie restriction; Mitochondria, reactive oxygen species, and cellular energetics; Nutrient effects beyond energy
7.	Lee JH, Budanov AV, Park EJ, Birse R, Kim TE, Perkins GA, et al. Sestrin as a feedback inhibitor of TOR that prevents age-related pathologies. Science. 2010 Mar 5;327(5970):1223-8. PubMed PMID: 20203043. Pubmed Central PMCID: 2866632.
	Themes:  mTOR
8.	Murphy EF, Cotter PD, Healy S, Marques TM, O'Sullivan O, Fouhy F, et al. Composition and energy harvesting capacity of the gut microbiota: relationship to diet, obesity and time in mouse models. Gut. 2010 Dec;59(12):1635-42. PubMed PMID: 20926643.
	Themes: Microbiome; Nutrient effects beyond energy
9.	Morselli E, Maiuri MC, Markaki M, Megalou E, Pasparaki A, Palikaras K, et al. Caloric restriction and resveratrol promote longevity through the Sirtuin-1-dependent induction of autophagy. Cell Death Dis. 2010;1:e10. PubMed PMID: 21364612. Pubmed Central PMCID: 3032517.
	Themes:  Autophagy (and proteostasis); Calorie restriction; Sirtuins
10.	Liao CY, Rikke BA, Johnson TE, Diaz V, Nelson JF. Genetic variation in the murine lifespan response to dietary restriction: from life extension to life shortening. Aging Cell. 2010 Feb;9(1):92-5. PubMed PMID: 19878144. Pubmed Central PMCID: 3476836.
Themes:  Calorie restriction
2011
11.	Baker DJ, Wijshake T, Tchkonia T, LeBrasseur NK, Childs BG, van de Sluis B, et al. Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders. Nature. 2011 Nov 10;479(7372):232-6. PubMed PMID: 22048312. Pubmed Central PMCID: 3468323.
	Themes: Aging-associated predictors of chronic disease; Telomeres relative to aging and energetics
12.	Burnett C, Valentini S, Cabreiro F, Goss M, Somogyvari M, Piper MD, et al. Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila. Nature. 2011 Sep 22;477(7365):482-5. PubMed PMID: 21938067. Pubmed Central PMCID: 3188402.
	Themes: Sirtuins
13.	Yoshino J, Mills KF, Yoon MJ, Imai S. Nicotinamide mononucleotide, a key NAD(+) intermediate, treats the pathophysiology of diet- and age-induced diabetes in mice. Cell Metab. 2011 Oct 5;14(4):528-36. PubMed PMID: 21982712. Pubmed Central PMCID: 3204926.
Themes: Diabetes/insulin resistance; Nutrient effects beyond energy; Sirtuins
14.	Sandovici I, Smith NH, Nitert MD, Ackers-Johnson M, Uribe-Lewis S, Ito Y, et al. Maternal diet and aging alter the epigenetic control of a promoter-enhancer interaction at the Hnf4a gene in rat pancreatic islets. Proc Natl Acad Sci U S A. 2011 Mar 29;108(13):5449-54. PubMed PMID: 21385945. Pubmed Central PMCID: 3069181.
Themes: Diabetes/insulin resistance
15.	Sai AJ, Walters RW, Fang X, Gallagher JC. Relationship between vitamin D, parathyroid hormone, and bone health. J Clin Endocrinol Metab. 2011 Mar;96(3):E436-46. PubMed PMID: 21159838. Pubmed Central PMCID: 3047227.
Themes: Aging-associated predictors of chronic disease
16.	Anisimov VN, Zabezhinski MA, Popovich IG, Piskunova TS, Semenchenko AV, Tyndyk ML, et al. Rapamycin increases lifespan and inhibits spontaneous tumorigenesis in inbred female mice. Cell Cycle. 2011 Dec 15;10(24):4230-6. PubMed PMID: 22107964.
Themes: mTOR
17.	Zhang FF, Cardarelli R, Carroll J, Fulda KG, Kaur M, Gonzalez K, et al. Significant differences in global genomic DNA methylation by gender and race/ethnicity in peripheral blood. Epigenetics : official journal of the DNA Methylation Society. 2011 May;6(5):623-9. PubMed PMID: 21739720. Pubmed Central PMCID: 3230547.
Themes: Aging-associated predictors of chronic disease
18.	Dominguez-Bello MG, Blaser MJ, Ley RE, Knight R. Development of the human gastrointestinal microbiota and insights from high-throughput sequencing. Gastroenterology. 2011 May;140(6):1713-9. PubMed PMID: 21530737.

Themes: Aging-associated predictors of chronic disease; Microbiome; Nutrient effects beyond energy
19.	Medina DX, Caccamo A, Oddo S. Methylene blue reduces abeta levels and rescues early cognitive deficit by increasing proteasome activity. Brain pathology. 2011 Mar;21(2):140-9. PubMed PMID: 20731659. Pubmed Central PMCID: 2992595.
	Themes: Autophagy (and proteostasis)
20.	Arner P, Bernard S, Salehpour M, Possnert G, Liebl J, Steier P, et al. Dynamics of human adipose lipid turnover in health and metabolic disease. Nature. 2011 Oct 6;478(7367):110-3. PubMed PMID: 21947005. Pubmed Central PMCID: 3773935.
Themes: Diabetes/insulin resistance; Mitochondria, reactive oxygen species, and cellular energetics
2012
21.	Park SJ, Ahmad F, Philp A, Baar K, Williams T, Luo H, et al. Resveratrol ameliorates aging-related metabolic phenotypes by inhibiting cAMP phosphodiesterases. Cell. 2012 Feb 3;148(3):421-33. PubMed PMID: 22304913. Pubmed Central PMCID: 3431801.
Themes: Diabetes/insulin resistance; Nutrient effects beyond energy; Sirtuins
22.	Claesson MJ, Jeffery IB, Conde S, Power SE, O'Connor EM, Cusack S, et al. Gut microbiota composition correlates with diet and health in the elderly. Nature. 2012 Aug 9;488(7410):178-84. PubMed PMID: 22797518.
	Themes: Microbiome; Nutrient effects beyond energy
23.	Mattison JA, Roth GS, Beasley TM, Tilmont EM, Handy AM, Herbert RL, et al. Impact of caloric restriction on health and survival in rhesus monkeys from the NIA study. Nature. 2012 Sep 13;489(7415):318-21. PubMed PMID: 22932268. Pubmed Central PMCID: 3832985.
Themes:  Calorie restriction
24.	Lamming DW, Ye L, Katajisto P, Goncalves MD, Saitoh M, Stevens DM, et al. Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity. Science. 2012 Mar 30;335(6076):1638-43. PubMed PMID: 22461615. Pubmed Central PMCID: 3324089.
Themes:  Diabetes/insulin resistance; mTOR
25.	Devkota S, Wang Y, Musch MW, Leone V, Fehlner-Peach H, Nadimpalli A, et al. Dietary-fat-induced taurocholic acid promotes pathobiont expansion and colitis in Il10-/- mice. Nature. 2012 Jul 5;487(7405):104-8. PubMed PMID: 22722865. Pubmed Central PMCID: 3393783.
Themes: Microbiome
26.	Yilmaz OH, Katajisto P, Lamming DW, Gultekin Y, Bauer-Rowe KE, Sengupta S, et al. mTORC1 in the Paneth cell niche couples intestinal stem-cell function to calorie intake. Nature. 2012 Jun 28;486(7404):490-5. PubMed PMID: 22722868. Pubmed Central PMCID: 3387287.
Themes:  Calorie restriction; mTOR

27.	Canto C, Houtkooper RH, Pirinen E, Youn DY, Oosterveer MH, Cen Y, et al. The NAD(+) precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet-induced obesity. Cell Metab. 2012 Jun 6;15(6):838-47. PubMed PMID: 22682224. Pubmed Central PMCID: 3616313.
	Themes: Diabetes/insulin resistance; Nutrient effects beyond energy; Sirtuins
28.	Matsubara J, Sugiyama S, Sugamura K, Nakamura T, Fujiwara Y, Akiyama E, et al. A dipeptidyl peptidase-4 inhibitor, des-fluoro-sitagliptin, improves endothelial function and reduces atherosclerotic lesion formation in apolipoprotein E-deficient mice. Journal of the American College of Cardiology. 2012 Jan 17;59(3):265-76. PubMed PMID: 22240132.
	Themes: Diabetes/insulin resistance
29.	Tieland M, Dirks ML, van der Zwaluw N, Verdijk LB, van de Rest O, de Groot LC, et al. Protein supplementation increases muscle mass gain during prolonged resistance-type exercise training in frail elderly people: a randomized, double-blind, placebo-controlled trial. Journal of the American Medical Directors Association. 2012 Oct;13(8):713-9. PubMed PMID: 22770932.
Themes: Nutrient effects beyond energy
30.	Tieland M, van de Rest O, Dirks ML, van der Zwaluw N, Mensink M, van Loon LJ, et al. Protein supplementation improves physical performance in frail elderly people: a randomized, double-blind, placebo-controlled trial. Journal of the American Medical Directors Association. 2012 Oct;13(8):720-6. PubMed PMID: 22889730.
Themes: Nutrient effects beyond energy
31.	Hughes AL, Gottschling DE. An early age increase in vacuolar pH limits mitochondrial function and lifespan in yeast. Nature. 2012 Dec 13;492(7428):261-5. PubMed PMID: 23172144. Pubmed Central PMCID: 3521838.
Themes:  Calorie restriction; Mitochondria, reactive oxygen species, and cellular energetics
2013
32.	Yoshimoto S, Loo TM, Atarashi K, Kanda H, Sato S, Oyadomari S, et al. Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome. Nature. 2013 Jul 4;499(7456):97-101. PubMed PMID: 23803760.
Themes: Microbiome
33.	Warr MR, Binnewies M, Flach J, Reynaud D, Garg T, Malhotra R, et al. FOXO3A directs a protective autophagy program in haematopoietic stem cells. Nature. 2013 Feb 21;494(7437):323-7. PubMed PMID: 23389440. Pubmed Central PMCID: 3579002.
Themes: Autophagy (and proteostasis)
34.	Cabreiro F, Au C, Leung KY, Vergara-Irigaray N, Cocheme HM, Noori T, et al. Metformin retards aging in C. elegans by altering microbial folate and methionine metabolism. Cell. 2013 Mar 28;153(1):228-39. PubMed PMID: 23540700. Pubmed Central PMCID: 3898468.
Themes: Nutrient effects beyond energy
35.	Martin-Montalvo A, Mercken EM, Mitchell SJ, Palacios HH, Mote PL, Scheibye-Knudsen M, et al. Metformin improves healthspan and lifespan in mice. Nature communications. 2013;4:2192. PubMed PMID: 23900241. Pubmed Central PMCID: 3736576.
Themes: Nutrient effects beyond energy; Mitochondria, reactive oxygen species, and cellular energetics
36.	Daniali L, Benetos A, Susser E, Kark JD, Labat C, Kimura M, et al. Telomeres shorten at equivalent rates in somatic tissues of adults. Nature communications. 2013;4:1597. PubMed PMID: 23511462. Pubmed Central PMCID: 3615479.
Themes: Aging-associated predictors of chronic disease; Telomeres relative to aging and energetics
37.	O'Rourke EJ, Ruvkun G. MXL-3 and HLH-30 transcriptionally link lipolysis and autophagy to nutrient availability. Nat Cell Biol. 2013 Jun;15(6):668-76. PubMed PMID: 23604316. Pubmed Central PMCID: 3723461.
Themes: Autophagy (and proteostasis); Nutrient effects beyond energy
38.	Okada-Iwabu M, Yamauchi T, Iwabu M, Honma T, Hamagami K, Matsuda K, et al. A small-molecule AdipoR agonist for type 2 diabetes and short life in obesity. Nature. 2013 Nov 28;503(7477):493-9. PubMed PMID: 24172895.
Themes: Diabetes/insulin resistance
39.	Schaart JG, Dubos C, Romero De La Fuente I, van Houwelingen AM, de Vos RC, Jonker HH, et al. Identification and characterization of MYB-bHLH-WD40 regulatory complexes controlling proanthocyanidin biosynthesis in strawberry (Fragaria x ananassa) fruits. The New phytologist. 2013 Jan;197(2):454-67. PubMed PMID: 23157553.
	Themes:
40.	Sene A, Khan AA, Cox D, Nakamura RE, Santeford A, Kim BM, et al. Impaired cholesterol efflux in senescent macrophages promotes age-related macular degeneration. Cell Metab. 2013 Apr 2;17(4):549-61. PubMed PMID: 23562078. Pubmed Central PMCID: 3640261.
Themes: Nutrient effects beyond energy; Mitochondria, reactive oxygen species, and cellular energetics
41.	Rana A, Rera M, Walker DW. Parkin overexpression during aging reduces proteotoxicity, alters mitochondrial dynamics, and extends lifespan. Proc Natl Acad Sci U S A. 2013 May 21;110(21):8638-43. PubMed PMID: 23650379. Pubmed Central PMCID: 3666724.
Themes: Autophagy (and proteostasis)