Variation Type Average number per individual Range across 993 individuals All Variation 21978 (19637-23009) - common 20970 (18793-21800) - low 848 (720-1036) - rare 160 (100-428) All Base substitutions 21270 (19043-22210) - common 20302 (18236-21069) - low 814 (689-982) - rare 154 (97-422) All Deletions 418 (290-476) - common 392 (271-439) - low 22 (8-41) - rare 4 (0-13) All Insertions 289 (234-333) - common 276 (226-318) - low 12 (3-26) - rare 2 (0-9) All Synonymous 9993 (8921-10406) - common 9632 (8607-10051) - low 313 (255-402) - rare 48 (21-159) All Nonsynonymous 8718 (7834-9114) - common 8221 (7424-8591) - low 407 (338-483) - rare 89 (57-218) All Splice-site 2494 (2195-2648) - common 2396 (2121-2525) - low 86 (60-123) - rare 12 (3-41) All Exon End 396 (355-443) - common 375 (336-416) - low 17 (6-31) - rare 4 (0-12) All Inframe 147 (113-179) - common 137 (104-169) - low 8 (0-20) - rare 1 (0-7) All Frameshifting Indels 99 (80-125) - common 90 (71-108) - low 6 (0-19) - rare 3 (0-11) All Stop-gain 57 (41-79) - common 49 (33-69) - low 5 (0-15) - rare 2 (0-11) All Essential Splice-site 55 (41-72) - common 50 (38-66) - low 3 (0-14) - rare 1 (0-7) All Initiator Methionine 10 (5-17) - common 10 (5-17) - low 1 (0-3) - rare 0 (0-2) All Stop-loss 9 (5-15) - common 9 (4-15) - low 0 (0-3) - rare 0 (0-2)